Phenotypes Associated with This Genotype

Genotype
MGI:5473713

• Allelic Composition: Mcm4^Sdla/Mcm4⁺
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased DN1 thymic pro-T cell number ( J:194117 )

enlarged spleen ( J:194117 )

• in moribund mice

enlarged lymph nodes ( J:194117 )

• in moribund mice

neoplasm

increased tumor incidence ( J:194117 )

• hematologic malignancy including mediastinal masses, splenomegaly and/or lymphadenopathy in 180 of 191 moribund mice

increased acute lymphoblastic leukemia incidence ( J:194117 )

• early onset T cell acute lymphoblastic leukemia (T-ALL)

cellular

induced chromosome breakage ( J:194117 )

• in mouse embryonic fibroblasts in the presence or absence of aphidicolin

spontaneous chromosome breakage ( J:194117 )

• in mouse embryonic fibroblasts in the presence or absence of aphidicolin

hematopoietic system

decreased DN1 thymic pro-T cell number ( J:194117 )

enlarged spleen ( J:194117 )

• in moribund mice

reticulocytosis ( J:194117 )

• 18-fold increase in micronucleated reticulocytes

endocrine/exocrine glands

decreased DN1 thymic pro-T cell number ( J:194117 )

growth/size/body

enlarged spleen ( J:194117 )

• in moribund mice