Phenotypes Associated with This Genotype

Genotype
MGI:5472015

• Allelic Composition: Gt(ROSA)26Sor^{tm1(RICTOR)Jger}/Gt(ROSA)26Sor^{tm1(RICTOR)Jger}; Tg(GFAP-cre)25Mes/0
• Genetic Background: involves: 129 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Gliomas in Gt(ROSA)26Sor^{tm1(RICTOR)Jger}/Gt(ROSA)26Sor^{tm1(RICTOR)Jger} Tg(GFAP-cre)25Mes/0 mice

mortality/aging

premature death ( J:192206 )

• most mice succumb to gliomas by 22 weeks

neoplasm

abnormal tumor vascularization ( J:192206 )

• intratumoral hemorrhage

increased glioma incidence ( J:192206 )

• bilateral, multifocal infiltrating glioma in the amygdalohippocampal region or surrounding cortex in close proximity to the subventricular zone

increased oligodendroglioma incidence ( J:192206 )

• infiltrating gliomas exhibit oligodendroglial-like features with the typical fried egg appearance

nervous system

increased glioma incidence ( J:192206 )

• bilateral, multifocal infiltrating glioma in the amygdalohippocampal region or surrounding cortex in close proximity to the subventricular zone

increased oligodendroglioma incidence ( J:192206 )

• infiltrating gliomas exhibit oligodendroglial-like features with the typical fried egg appearance

abnormal postnatal subventricular zone morphology ( J:192206 )

• 2-fold increase in thickness

cardiovascular system

abnormal tumor vascularization ( J:192206 )

• intratumoral hemorrhage