Phenotypes Associated with This Genotype

Genotype
MGI:5471802

• Allelic Composition: Tg(CAG-EGFP/Map1lc3b)53Nmz/0; Tg(Myh6-Gsk3b*)19Jusa/0
• Genetic Background: involves: C57BL/6NCrj * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased myocardial infarct size ( J:186597 )

• following 2 hours of ischemia without reperfusion

• however, treatment with rapamycin reduces infarct size

cellular

abnormal autophagy ( J:186597 )

• reduced autophagy in the heart following 2 hours of ischemia or ischemia with reperfusion

• however, treatment with rapamycin restores autophagy in both cases

homeostasis/metabolism

increased myocardial infarct size ( J:186597 )

• following 2 hours of ischemia without reperfusion

• however, treatment with rapamycin reduces infarct size

abnormal autophagy ( J:186597 )

• reduced autophagy in the heart following 2 hours of ischemia or ischemia with reperfusion

• however, treatment with rapamycin restores autophagy in both cases