Phenotypes Associated with This Genotype

Genotype
MGI:5471747

• Allelic Composition: Drd2^tm1.1Mrub/Drd2^tm1.1Mrub; Tg(Prl-cre)1Mrub/?
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

growth/size/body region phenotype ( J:194227 )

♂N • body weight and body size are normal in males

homeostasis/metabolism

increased circulating prolactin level ( J:194227 )

• hyperprolactinemia in both sexes but particularly in females

decreased physiological sensitivity to xenobiotic ( J:194227 )

• haloperidol fails to increase serum prolactin in either sex as it does in controls

• haloperidol induces catatonia as in controls