About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5471365
Allelic
Composition
Atg7tm1Tchi/Atg7tm1Tchi
Slc6a3tm1(cre)Xz/Slc6a3+
Genetic
Background
involves: 129S1/Sv * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg7tm1Tchi mutation (1 available); any Atg7 mutation (30 available)
Slc6a3tm1(cre)Xz mutation (2 available); any Slc6a3 mutation (50 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice are more active during the wake cycle than controls at 7 months of age but this difference is no longer significant at 12 months of age

homeostasis/metabolism
• mice exhibit an age dependent decrease in striatal dopamine content in the brain, with a 55.5% reduction by 7-9 months of age compared to controls

nervous system
• 40% loss of substantia nigra pars compacta dopamine neurons by 7-9 months of age
• neuronal inclusions are present in the substantia nigra pars compacta
• inclusions are often perinuclear but are also in the neuropil and are positive for ubiquitin
• neuronal inclusions are present in juveniles but are smaller in size than at older ages
• 40% loss of substantia nigra pars compacta dopamine neurons by 7-9 months of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Parkinson's disease DOID:14330 OMIM:607688
OMIM:610297
OMIM:613643
OMIM:614251
OMIM:PS168600
J:192452


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/10/2019
MGI 6.14
The Jackson Laboratory