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Phenotypes Associated with This Genotype
Genotype
MGI:5471363
Allelic
Composition
Atg7tm1Tchi/Atg7tm1Tchi
En1tm2(cre)Wrst/En1+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg7tm1Tchi mutation (1 available); any Atg7 mutation (30 available)
En1tm2(cre)Wrst mutation (1 available); any En1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice show a 76% reduction in survival by 1 year of age
• mice show a 76% reduction in survival by 1 year of age

growth/size/body

behavior/neurological
• mice exhibit tremulousness
• mice show decreased locomotor activity
• mice exhibit a wide-based and ataxic gait

homeostasis/metabolism
• mice exhibit an age dependent decrease in striatal dopamine content in the brain, with a 64.5% reduction by 7-9 months of age compared to controls

nervous system
• while alpha-synuclein inclusions are not seen, accumulation of low-molecular weight alpha-synuclein is seen in the brain
• 60% loss of substantia nigra pars compacta dopamine neurons by 7-9 months of age
• a modest increase in reactive astrocytes in the of substantia nigra pars compacta
• neuronal inclusions are present in the substantia nigra pars compacta
• inclusions are often perinuclear but are also in the neuropil and are positive for ubiquitin
• neuronal inclusions are present in juveniles but are smaller in size than at older ages
• 60% loss of substantia nigra pars compacta dopamine neurons by 7-9 months of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Parkinson's disease DOID:14330 OMIM:607688
OMIM:610297
OMIM:613643
OMIM:614251
OMIM:PS168600
J:192452


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory