Phenotypes Associated with This Genotype

Genotype
MGI:5471253

• Allelic Composition: Runx1^tm3Spe/Runx1^tm3Spe; Slc17a8^tm1(cre)Lowl/Slc17a8⁺
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:193903 )

N • thermal nociception, chemical nociception, and neuropathic mechanical pain are not markedly affected in mutants

N • mechanical allodynia is unaffected in mutants

hypoalgesia ( J:193903 )

• intraplantar injection of carrageenan still induces mechanical hypersensitivity in mutants, but a modest (significant) increase in mechanical thresholds compared to controls is observed (higher magnitude of mechanical stimulus required to evoke paw withdrawal)