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Phenotypes Associated with This Genotype
Genotype
MGI:5471136
Allelic
Composition
Gpsm1tm1.1Lajb/Gpsm1tm1.1Lajb
Pkd1tm1.1Fqi/Pkd1tm1.1Fqi
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpsm1tm1.1Lajb mutation (1 available); any Gpsm1 mutation (42 available)
Pkd1tm1.1Fqi mutation (0 available); any Pkd1 mutation (153 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• plasma creatinine is increased in mice compared to single Pkd1 homozygotes at P11-12
• blood urea nitrogen is higher in mice compared to single Pkd1 homozygotes at P19

renal/urinary system
• mice exhibit an increase in cyst progression compared to single Pkd1 homozygotes
• proliferating cell nuclear antigen-positive renal cystic epithelial cells are higher than in single Pkd1 homozygous kidneys
• kidney-to-body weight ratio is higher than in single Pkd1 homozygotes or wild-type mice at P11-12
• renal function is reduced in double mutants more than in single Pkd1 homozygotes as indicating by a larger increase in blood urea nitrogen and plasma creatinine levels

growth/size/body
• mice exhibit an increase in cyst progression compared to single Pkd1 homozygotes
• proliferating cell nuclear antigen-positive renal cystic epithelial cells are higher than in single Pkd1 homozygous kidneys
• kidney-to-body weight ratio is higher than in single Pkd1 homozygotes or wild-type mice at P11-12

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
polycystic kidney disease 1 DOID:0110858 OMIM:173900
J:193175


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory