Mouse Genome Informatics
cx
    Gpsm1tm1.1Lajb/Gpsm1tm1.1Lajb
Pkd1tm1.1Fqi/Pkd1tm1.1Fqi

involves: 129S6/SvEvTac
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
homeostasis/metabolism
• plasma creatinine is increased in mice compared to single Pkd1 homozygotes at P11-12
• blood urea nitrogen is higher in mice compared to single Pkd1 homozygotes at P19

renal/urinary system
• kidney-to-body weight ratio is higher than in single Pkd1 homozygotes or wild-type mice at P11-12
• mice exhibit an increase in cyst progression compared to single Pkd1 homozygotes
• proliferating cell nuclear antigen-positive renal cystic epithelial cells are higher than in single Pkd1 homozygous kidneys
• renal function is reduced in double mutants more than in single Pkd1 homozygotes as indicating by a larger increase in blood urea nitrogen and plasma creatinine levels

Mouse Models of Human Disease
OMIM IDRef(s)
Polycystic Kidney Disease 1; PKD1 173900 J:193175