Phenotypes Associated with This Genotype

Genotype
MGI:5471121

• Allelic Composition: Kdr^tm1Wag/Kdr^tm1Wag; Nfatc1^tm1.1(cre)Bz/Nfatc1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:193198 )

• all die prior to birth (after or during E14.5-16.5)

growth/size/body

decreased body size ( J:193198 )

• observed after E14.5 through 16.5

cardiovascular system

abnormal coronary artery morphology ( J:193198 )

• E14.5 embryos have severely diminished or absent coronary arteries, but coronary veins develop

abnormal angiogenesis ( J:193198 )

• a 24% reduction of subepicardial endothelial cell population (for vein formation) is detected at E14.5, with a 74% decrease in intramyocardial endothelial cells (for artery formation) detected

• E12.5 mutants do not develop coronary plexuses in the peritruncal/coronary sulcus area or ventricular septum

abnormal interventricular septum morphology ( J:193198 )

• E12.5 mutants do not develop coronary plexuses in the ventricular septum

heart hemorrhage ( J:193198 )

• embryos develop cardiac hemorrhages at E14.5-16.5