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Phenotypes Associated with This Genotype
Genotype
MGI:5470230
Allelic
Composition		 Rr96tm1.1Tich/Rr96tm1.1Tich
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic
Background		 involves: 129 * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(rtTA*M2)Jae mutation (32 available); any Gt(ROSA)26Sor mutation (1062 available)
Rr96tm1.1Tich mutation (0 available); any Rr96 mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:191711 )
• doxycycline treatment leads to detectable CD4+ CD8+ cells after 2 days
• levels of double positive cells reach 47% by 17 days after the start of treatment

hematopoietic system
abnormal T cell differentiation ( J:191711 )
• doxycycline treatment leads to detectable CD4+ CD8+ cells after 2 days
• levels of double positive cells reach 47% by 17 days after the start of treatment

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory