Phenotypes Associated with This Genotype

Genotype
MGI:5470229

• Allelic Composition: Rr96^tm1.1Tich/Rr96⁺; Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal CD4-positive T cell differentiation ( J:191711 )

• 15 days of doxycycline exposure leads to CD4 induction in all but the earliest CD4^- thymocytes (not in DN1-3)

• only about 30% of peripheral CD8 cells begin expressing CD4

hematopoietic system

abnormal CD4-positive T cell differentiation ( J:191711 )

• 15 days of doxycycline exposure leads to CD4 induction in all but the earliest CD4^- thymocytes (not in DN1-3)

• only about 30% of peripheral CD8 cells begin expressing CD4