Phenotypes Associated with This Genotype

Genotype
MGI:5469879

• Allelic Composition: Syngap1^tm2Geno/Syngap1⁺; Tg(CAG-cre/Esr1*)5Amc/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavior ( J:193208 )

• mice exhibit behavioral abnormalities as in Syngap1^tm1Rlh heterozygotes

abnormal spatial working memory ( J:193208 )

• untreated mice and mice treated with tamoxifen in adulthood exhibit absence of spontaneous alteration in a T-maze compared with control mice

decreased anxiety-related response ( J:193208 )

• untreated mice and mice treated with tamoxifen in adulthood spend increased time in open arms of an elevated plus maze compared with control mice

hyperactivity ( J:193208 )

• untreated mice and mice treated with tamoxifen in adulthood exhibit increased activity in an open field compared with control mice