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Phenotypes Associated with This Genotype
Genotype
MGI:5469877
Allelic
Composition		 Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Syngap1tm1.1Geno/Syngap1+
Genetic
Background		 involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * C57BL/6NCr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm9(CAG-tdTomato)Hze mutation (4 available); any Gt(ROSA)26Sor mutation (944 available)
Syngap1tm1.1Geno mutation (1 available); any Syngap1 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal CNS synaptic transmission ( J:193208 )
• adult injection of cre-expressing virus produces an increase in intrinsic excitability of dentate gyrus neurons compared with control mice
abnormal glutamate-mediated receptor currents ( J:193208 )
• mice injected with a cre-expressing virus exhibit an increase in dentate gyrus neuron AMPA/NMDA ratio compared with control mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory