Phenotypes Associated with This Genotype

Genotype
MGI:5469863

• Allelic Composition: Slc17a6^tm1.1Jder/Slc17a6^tm1.1Jder; Emx1^tm1(cre)Krj/Emx1⁺
• Genetic Background: B6.Cg-Emx1^tm1(cre)Krj Slc17a6^tm1.1Jder

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal dendrite morphology ( J:192240 )

• adult CA1 hippocampal pyramidal neurons exhibit reduced dendritic arbor and reduced number of spines compared with control mice

abnormal dendritic spine morphology ( J:192240 )

• reduced number of spines in adult CA1 hippocampal pyramidal neurons exhibit

abnormal glutamate-mediated receptor currents ( J:192240 )

• young mice exhibit reduced evoked synaptic glutamatergic transmission in CA3-CA1 connections compared with control mice

reduced long-term depression ( J:192240 )

• in young CA3-CA1 connections

decreased synaptic glutamate release ( J:192240 )

• decreased evoked glutamate release probability

increased paired-pulse ratio ( J:192240 )

• increased paired-pulse ratio with decreased evoked release probability in young CA3-CA1 connections

behavior/neurological

increased exploration in new environment ( J:192240 )

abnormal spatial learning ( J:192240 )

• impaired spatial learning and memory in a Morris water maze

• however, treatment with D-Serine and D-amino acid oxidase inhibition enhances learning

abnormal spatial reference memory ( J:192240 )

• impaired spatial learning and memory in a Morris water maze

growth/size/body

decreased body size ( J:192240 )

• at P14 without a decrease in body weight