Phenotypes Associated with This Genotype

Genotype
MGI:5469373

• Allelic Composition: Col1a1^{tm1(tetO-CTNNB1)Tcd}/Col1a1⁺; Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:193365 )

N • doxycycline-treated mice exhibit normal villus compartment

abnormal enterocyte apoptosis ( J:193365 )

• docycycline-treated mice exhibit apoptosis all along the enlarged crypt axis instead of being restricted to the bottom of the crypt as in control mice

increased enterocyte apoptosis ( J:193365 )

• upon withdrawal of doxycycline

abnormal enterocyte proliferation ( J:193365 )

• increased in the crypt compartment of doxycycline-treated mice

abnormal intestine development ( J:193365 )

• doxycycline-treated mice exhibit partially altered intestinal differentiation compared with control mice

abnormal crypts of Lieberkuhn morphology ( J:193365 )

• enlarged crypts in doxycycline-treated mice

• however, withdrawal of doxycycline leads to a rapid regression of the crypt compartment

growth/size/body

decreased body weight ( J:193365 )

• in docycycline-treated mice

endocrine/exocrine glands

abnormal crypts of Lieberkuhn morphology ( J:193365 )

• enlarged crypts in doxycycline-treated mice

• however, withdrawal of doxycycline leads to a rapid regression of the crypt compartment

cellular

abnormal enterocyte apoptosis ( J:193365 )

• docycycline-treated mice exhibit apoptosis all along the enlarged crypt axis instead of being restricted to the bottom of the crypt as in control mice

increased enterocyte apoptosis ( J:193365 )

• upon withdrawal of doxycycline

abnormal enterocyte proliferation ( J:193365 )

• increased in the crypt compartment of doxycycline-treated mice