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Phenotypes Associated with This Genotype
Genotype
MGI:5469079
Allelic
Composition
Map3k2tm1Rdbr/Map3k2tm1Rdbr
Genetic
Background
involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k2tm1Rdbr mutation (0 available); any Map3k2 mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system

cardiovascular system
• mice subjected to chronic hypoxia to induce pulmonary hypertension exhibit attenuated right ventricle hypertrophy and cardiac myocyte hypertrophy compared with wild-type mice
• however, mice exhibit pulmonary hypertension when exposed to chronic

homeostasis/metabolism
• mice subjected to chronic hypoxia to induce pulmonary hypertension exhibit attenuated right ventricle hypertrophy and cardiac myocyte hypertrophy compared with wild-type mice
• however, mice exhibit pulmonary hypertension when exposed to chronic


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory