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Phenotypes Associated with This Genotype
Genotype
MGI:5468941
Allelic
Composition		 Cxcl12tm1Tng/Cxcl12tm1.1Link
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CD-1 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcl12tm1.1Link mutation (1 available); any Cxcl12 mutation (24 available)
Cxcl12tm1Tng mutation (1 available); any Cxcl12 mutation (24 available)
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal blood cell morphology/development ( J:193594 )
• the numbers of colony-forming cells and KSL cells are increased in the blood and spleen, demonstrating constitutive HPC mobilization, compared with control mice
decreased B cell number ( J:193594 )
• in the bone marrow
decreased hematopoietic stem cell number ( J:193594 )
• modest decrease in the absolute number
abnormal hematopoietic stem cell physiology ( J:193594 )
• increased cycling of more mature KSL progenitors in the blood
• however, hematopoietic stem cell cycling is normal

immune system
decreased B cell number ( J:193594 )
• in the bone marrow

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/28/2024
MGI 6.13 		The Jackson Laboratory