mortality/aging
nervous system
• synapses accumulate clathrin-coated vesicles but not clathrin-coated pits
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• reduced number
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• endocytic recovery of synaptic vesicle is 2.5-fold slower than in controls
• however, this defect is rescued by re-expression of Sh3gl1
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• reduction in peak amplitude in response to a single stimulus
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• more than 2.5 times reduction in the frequency and decreased amplitude
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• after a 30 AP at 10, but not 1, Hz stimulus
• recovering is delayed
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respiratory system
behavior/neurological
growth/size/body