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Phenotypes Associated with This Genotype
Genotype
MGI:5468831
Allelic
Composition
Sh3gl1tm1Pdc/Sh3gl1tm1Pdc
Sh3gl2tm1Pdc/Sh3gl2tm1Pdc
Sh3gl3tm1.2Itl/Sh3gl3tm1.2Itl
Genetic
Background
involves: 129S1/Sv * C57BL/6 * C57BL/6J * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh3gl1tm1Pdc mutation (1 available); any Sh3gl1 mutation (37 available)
Sh3gl2tm1Pdc mutation (1 available); any Sh3gl2 mutation (37 available)
Sh3gl3tm1.2Itl mutation (0 available); any Sh3gl3 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

nervous system
• synapses accumulate clathrin-coated vesicles but not clathrin-coated pits
• endocytic recovery of synaptic vesicle is 2.5-fold slower than in controls
• however, this defect is rescued by re-expression of Sh3gl1
• reduction in peak amplitude in response to a single stimulus
• more than 2.5 times reduction in the frequency and decreased amplitude
• after a 30 AP at 10, but not 1, Hz stimulus
• recovering is delayed

respiratory system

behavior/neurological

growth/size/body


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory