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Phenotypes Associated with This Genotype
Genotype
MGI:5468723
hm1
Allelic
Composition		 Pnpbata/Pnpbata
Genetic
Background		 C57BL/6JSfdAnu-Pnpbata
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pnpbata mutation (2 available); any Pnp mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased B cell proliferation ( J:104190 )
• decreased in vitro proliferation of IL-17 stimulated bone marrow B cells that bind to antibodies against IgM
decreased marginal zone B cell number ( J:104190 )
• age-dependent decrease in marginal zone B cells
increased T follicular helper cell number ( J:104190 )
• age-dependent increase in CD44hi ICOShi CD4+ T cells

immune system
decreased B cell proliferation ( J:104190 )
• decreased in vitro proliferation of IL-17 stimulated bone marrow B cells that bind to antibodies against IgM
decreased marginal zone B cell number ( J:104190 )
• age-dependent decrease in marginal zone B cells
increased T follicular helper cell number ( J:104190 )
• age-dependent increase in CD44hi ICOShi CD4+ T cells

cellular
decreased B cell proliferation ( J:104190 )
• decreased in vitro proliferation of IL-17 stimulated bone marrow B cells that bind to antibodies against IgM

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory