Phenotypes Associated with This Genotype

Genotype
MGI:5468721

• Allelic Composition: Fcgr2b^tm1Kgcs/Fcgr2b⁺
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased B cell apoptosis ( J:190890 )

• after immunization

increased germinal center B cell number ( J:190890 )

• after immunization

increased IgG1 level ( J:190890 )

• NP-specific IgG1 early after immunization with NP-KLH

• NP-specific IgM secreting cells in the spleen and bone marrow after immunization with NP-KLH

• NP-specific IgG1 in the first week after NP-KLH immunization

increased IgG3 level ( J:190890 )

• NP-specific IgG3 early after immunization with NP-Ficoll

increased IgM level ( J:190890 )

• NP-specific IgM early after immunization with NP-KLH or NP-Ficoll

• NP-specific IgM secreting cells in the spleen and bone marrow after immunization with NP-KLH

increased susceptibility to induced arthritis ( J:190890 )

• in a collagen-induced arthritis model, mice develop arthritic sooner and with greater severity compared with wild-type mice

increased anti-chromatin antibody level ( J:190890 )

• after secondary immunization with NP-KLH

• spontaneously after 14 months

increased anti-double stranded DNA antibody level ( J:190890 )

• 8, but not 11, days after NP-KLH immunization

• after secondary immunization with NP-KLH

• spontaneously after 14 months

skeleton

increased susceptibility to induced arthritis ( J:190890 )

• in a collagen-induced arthritis model, mice develop arthritic sooner and with greater severity compared with wild-type mice

renal/urinary system

renal glomerular protein deposits ( J:190890 )

♀ • female mice spontaneously develop pronounced glomerular immune complex deposition unlike wild-type mice

♀ • however, kidney function is normal

cellular

decreased B cell apoptosis ( J:190890 )

• after immunization

hematopoietic system

decreased B cell apoptosis ( J:190890 )

• after immunization

increased germinal center B cell number ( J:190890 )

• after immunization

increased IgG1 level ( J:190890 )

• NP-specific IgG1 early after immunization with NP-KLH

• NP-specific IgM secreting cells in the spleen and bone marrow after immunization with NP-KLH

• NP-specific IgG1 in the first week after NP-KLH immunization

increased IgG3 level ( J:190890 )

• NP-specific IgG3 early after immunization with NP-Ficoll

increased IgM level ( J:190890 )

• NP-specific IgM early after immunization with NP-KLH or NP-Ficoll

• NP-specific IgM secreting cells in the spleen and bone marrow after immunization with NP-KLH