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Phenotypes Associated with This Genotype
Genotype
MGI:5468651
Allelic
Composition		 Ccnd3tm1Pisc/Ccnd3tm1Pisc
Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic
Background		 involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd3tm1Pisc mutation (0 available); any Ccnd3 mutation (507 available)
Cdkn1btm1Mlf mutation (2 available); any Cdkn1b mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell proliferation ( J:192031 )
• of pre-T cells as in Ccnd3tm1Pisc homozygotes
thymus hypoplasia ( J:192031 )
• not as severe as in Ccnd3tm1Pisc homozygotes
decreased double-positive T cell number ( J:192031 )
• as in Ccnd3tm1Pisc homozygotes

hematopoietic system
decreased T cell proliferation ( J:192031 )
• of pre-T cells as in Ccnd3tm1Pisc homozygotes
thymus hypoplasia ( J:192031 )
• not as severe as in Ccnd3tm1Pisc homozygotes
decreased double-positive T cell number ( J:192031 )
• as in Ccnd3tm1Pisc homozygotes
abnormal bone marrow cell physiology ( J:192031 )
• bone marrow progenitor cells transfected with a retrovirus encoding the constitutively active intracellular domain of Notch1 slightly delays development of T cell acute lymphoblastic leukemia in recipient irradiated wild-type mice from the

endocrine/exocrine glands
thymus hypoplasia ( J:192031 )
• not as severe as in Ccnd3tm1Pisc homozygotes

cellular
decreased T cell proliferation ( J:192031 )
• of pre-T cells as in Ccnd3tm1Pisc homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory