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Phenotypes Associated with This Genotype
Genotype
MGI:5468650
Allelic
Composition		 Ccnd3tm1.1(Ccnd2)Iaai/Ccnd3tm1.1(Ccnd2)Iaai
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd3tm1.1(Ccnd2)Iaai mutation (0 available); any Ccnd3 mutation (507 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell proliferation ( J:192031 )
• of pre-B cells as in Ccnd3tm1Pisc homozygotes
decreased T cell proliferation ( J:192031 )
• of pro- and pre-T cells as in Ccnd3tm1Pisc homozygotes
small thymus ( J:192031 )
• as in Ccnd3tm1Pisc homozygotes
thymus hypoplasia ( J:192031 )
• as in Ccnd3tm1Pisc homozygotes
decreased double-positive T cell number ( J:192031 )
• as in Ccnd3tm1Pisc homozygotes
decreased pre-B cell number ( J:192031 )
• as in Ccnd3tm1Pisc homozygotes

hematopoietic system
decreased B cell proliferation ( J:192031 )
• of pre-B cells as in Ccnd3tm1Pisc homozygotes
decreased T cell proliferation ( J:192031 )
• of pro- and pre-T cells as in Ccnd3tm1Pisc homozygotes
small thymus ( J:192031 )
• as in Ccnd3tm1Pisc homozygotes
thymus hypoplasia ( J:192031 )
• as in Ccnd3tm1Pisc homozygotes
decreased double-positive T cell number ( J:192031 )
• as in Ccnd3tm1Pisc homozygotes
decreased bone marrow cell number ( J:192031 )
• as in Ccnd3tm1Pisc homozygotes
decreased pre-B cell number ( J:192031 )
• as in Ccnd3tm1Pisc homozygotes
abnormal bone marrow cell physiology ( J:192031 )
• bone marrow progenitor cells transfected with a retrovirus encoding the constitutively active intracellular domain of Notch1 protect recipient irradiated wild-type mice from the development of T cell acute lymphoblastic leukemia

endocrine/exocrine glands
small thymus ( J:192031 )
• as in Ccnd3tm1Pisc homozygotes
thymus hypoplasia ( J:192031 )
• as in Ccnd3tm1Pisc homozygotes

cellular
decreased B cell proliferation ( J:192031 )
• of pre-B cells as in Ccnd3tm1Pisc homozygotes
decreased T cell proliferation ( J:192031 )
• of pro- and pre-T cells as in Ccnd3tm1Pisc homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory