Phenotypes Associated with This Genotype

Genotype
MGI:5467842

• Allelic Composition: Mirc14^tm1.2Czc/Mirc14^tm1.2Czc
• Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor) or (involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased thymocyte number ( J:188125 )

• decreased earliest thymic T-cell progenitors

decreased DN3 thymocyte number ( J:188125 )

decreased double-positive T cell number ( J:188125 )

increased marginal zone B cell number ( J:188125 )

decreased B cell number ( J:188125 )

• peripheral

decreased germinal center B cell number ( J:188125 )

increased CD4-positive, alpha-beta T cell number ( J:188125 )

neoplasm

increased tumor latency ( J:188125 )

• delayed T cell acute lymphoblastic leukemia (T-ALL) development in a transplantation model involving viral expression of the intracellular domain of Notch1

hematopoietic system

decreased thymocyte number ( J:188125 )

• decreased earliest thymic T-cell progenitors

decreased DN3 thymocyte number ( J:188125 )

decreased double-positive T cell number ( J:188125 )

increased marginal zone B cell number ( J:188125 )

decreased B cell number ( J:188125 )

• peripheral

decreased germinal center B cell number ( J:188125 )

increased CD4-positive, alpha-beta T cell number ( J:188125 )

endocrine/exocrine glands

decreased thymocyte number ( J:188125 )

• decreased earliest thymic T-cell progenitors

decreased DN3 thymocyte number ( J:188125 )