Phenotypes Associated with This Genotype

Genotype
MGI:5467642

• Allelic Composition: H2-Oa/Brd2^{Tg(otx2-lacZ)F5pImat}/H2-Oa/Brd2^{Tg(otx2-lacZ)F5pImat}
• Genetic Background: involves: CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:188139 )

• by E13.5

embryo

embryonic growth retardation ( J:188139 )

• in most mice at E10.5

abnormal neural tube morphology ( J:188139 )

• cranial neural tube defects in most mice at E10.5

abnormal embryonic neuroepithelium morphology ( J:188139 )

• severely distorted at the level of the rostral rhombencephalon

abnormal embryonic neuroepithelial layer differentiation ( J:188139 )

• neuroepithelial cells exhibit impaired differentiation with failure to exit the cell cycle compared with wild-type cells

increased embryonic neuroepithelium thickness ( J:188139 )

• irregularly thickened at the level of the rostral rhombencephalon

nervous system

increased embryonic neuroepithelium apoptosis ( J:188139 )

• increased cell death in the neuroepithelium at E10.5

abnormal neural tube morphology ( J:188139 )

• cranial neural tube defects in most mice at E10.5

abnormal embryonic neuroepithelium morphology ( J:188139 )

• severely distorted at the level of the rostral rhombencephalon

abnormal embryonic neuroepithelial layer differentiation ( J:188139 )

• neuroepithelial cells exhibit impaired differentiation with failure to exit the cell cycle compared with wild-type cells

increased embryonic neuroepithelium thickness ( J:188139 )

• irregularly thickened at the level of the rostral rhombencephalon

craniofacial

abnormal craniofacial morphology ( J:188139 )

• in most mice at E10.5

growth/size/body

embryonic growth retardation ( J:188139 )

• in most mice at E10.5

cellular

abnormal cell cycle ( J:188139 )

• neuroepithelial cells exhibit impaired differentiation with failure to exit the cell cycle compared with wild-type cells

increased embryonic neuroepithelium apoptosis ( J:188139 )

• increased cell death in the neuroepithelium at E10.5