Analysis Tools
mortality/aging
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• some diphtheria toxin-treated mice must be euthanized due to sustained vestibulomotor problems and weight loss
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hearing/vestibular/ear
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• fragmented 7 days after diphtheria toxin treatment
• replacement hair cells in diphtheria toxin-treated mice have short stereociliary bundles, multipolar shapes and innervation characteristic of type II hair cells
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• in diphtheria toxin-treated mice
• a higher doses does not increase hair cell loss
• however, mice exhibit some hair cell replacement in the lateral extrastriolar region of the utricle with neural elements
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• disorganized 7 days after diphtheria toxin treatment
• after 14 days of diphtheria toxin treatment, remaining hair cells exhibit either a long bundle of stereocilia, a very short bundle or no bundle concentrated in the presumed lateral extrastriolar region
• replacement hair cells in diphtheria toxin-treated mice have short stereociliary bundles, multipolar shapes and innervation characteristic of type II hair cells
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• expansion of supporting cells 7 days after diphtheria toxin treatment with occupation of most of the sensory epithelium after 14 days of diphtheria toxin treatment
• supporting cell densities decline as hair cells are replaced in diphtheria toxin-treated mice
• supporting cells are converted directly into hair cells in diphtheria toxin-treated mice and are not being rapidly replaced by supporting cell division following diphtheria toxin-mediated hair cell damage
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• at 3 and 7 days post-diphtheria toxin treatment, mice exhibit vestibulomotor dysfunction that persists as late as 180 days post treatment
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behavior/neurological
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• at 3 and 7 days post-diphtheria toxin treatment, mice exhibit vestibulomotor dysfunction that persists as late as 180 days post treatment
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head bobbing
(
J:191218
)
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• at 3 and 7 days post-diphtheria toxin treatment
• however, symptoms are improved by assistance of fluid injections and high calorie food supplementation
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• staggering gait at 3 and 7 days post-diphtheria toxin treatment
• however, symptoms are improved by assistance of fluid injections and high calorie food supplementation
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• at 3 and 7 days post-diphtheria toxin treatment
• however, symptoms are improved by assistance of fluid injections and high calorie food supplementation
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growth/size/body
weight loss
(
J:191218
)
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• at 3 and 7 days post-diphtheria toxin treatment
• however, symptoms are improved by assistance of fluid injections and high calorie food supplementation
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nervous system
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• fragmented 7 days after diphtheria toxin treatment
• replacement hair cells in diphtheria toxin-treated mice have short stereociliary bundles, multipolar shapes and innervation characteristic of type II hair cells
|
|
• in diphtheria toxin-treated mice
• a higher doses does not increase hair cell loss
• however, mice exhibit some hair cell replacement in the lateral extrastriolar region of the utricle with neural elements
|
|
• disorganized 7 days after diphtheria toxin treatment
• after 14 days of diphtheria toxin treatment, remaining hair cells exhibit either a long bundle of stereocilia, a very short bundle or no bundle concentrated in the presumed lateral extrastriolar region
• replacement hair cells in diphtheria toxin-treated mice have short stereociliary bundles, multipolar shapes and innervation characteristic of type II hair cells
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