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Phenotypes Associated with This Genotype
Genotype
MGI:5467513
Allelic
Composition
Ric8atm1.1Zhua/Ric8atm1.1Zhua
Tg(GFAP-cre)25Mes/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ric8atm1.1Zhua mutation (0 available); any Ric8a mutation (29 available)
Tg(GFAP-cre)25Mes mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• impaired migration from the external to internal granule layer
• severely disorganized
• Bergmann glial scaffolds surrounding he primary and secondary fissures are severely disorganized
• the Bergmann glial scaffolds surrounding other fissures is severely reduced in fiber density compared to in wild-type mice
• severely reduced Bergmann glia-basement membrane interaction compared to in wild-type mice
• however, the Bergmann glial scaffolds surrounding other fissures is still associated with basement membrane
• no basement membrane separates neighboring lobules in the cerebellum and remains on the surface
• however, granule cell precursors are normal
• no basement membrane separates neighboring lobules
• however, folial pattern is more or less normal
• scattered over a wide area in the cerebellum and frequently intermingled with ectopic granule cells
• most obvious in lobules surrounding the primary and secondary fissures
• throughout the molecular layer and external granule layer (EGL) surrounding the primary and secondary fissures
• in the EGL, but not the molecular layer, surrounding other lobules
• primary and secondary fissures
• no basement membrane separates neighboring lobules
• however, folial pattern is more or less normal
• expanded volume from P0 to P4

behavior/neurological

cellular
• Bergmann glial scaffolds surrounding he primary and secondary fissures are severely disorganized
• the Bergmann glial scaffolds surrounding other fissures is severely reduced in fiber density compared to in wild-type mice
• severely reduced Bergmann glia-basement membrane interaction compared to in wild-type mice
• however, the Bergmann glial scaffolds surrounding other fissures is still associated with basement membrane
• impaired migration from the external to internal granule layer
• no basement membrane separates neighboring lobules in the cerebellum and remains on the surface


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory