nervous system
• impaired migration from the external to internal granule layer
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• severely disorganized
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• Bergmann glial scaffolds surrounding he primary and secondary fissures are severely disorganized
• the Bergmann glial scaffolds surrounding other fissures is severely reduced in fiber density compared to in wild-type mice
• severely reduced Bergmann glia-basement membrane interaction compared to in wild-type mice
• however, the Bergmann glial scaffolds surrounding other fissures is still associated with basement membrane
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• no basement membrane separates neighboring lobules in the cerebellum and remains on the surface
• however, granule cell precursors are normal
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• no basement membrane separates neighboring lobules
• however, folial pattern is more or less normal
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• scattered over a wide area in the cerebellum and frequently intermingled with ectopic granule cells
• most obvious in lobules surrounding the primary and secondary fissures
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• throughout the molecular layer and external granule layer (EGL) surrounding the primary and secondary fissures
• in the EGL, but not the molecular layer, surrounding other lobules
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• primary and secondary fissures
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• no basement membrane separates neighboring lobules
• however, folial pattern is more or less normal
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• expanded volume from P0 to P4
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behavior/neurological
cellular
• Bergmann glial scaffolds surrounding he primary and secondary fissures are severely disorganized
• the Bergmann glial scaffolds surrounding other fissures is severely reduced in fiber density compared to in wild-type mice
• severely reduced Bergmann glia-basement membrane interaction compared to in wild-type mice
• however, the Bergmann glial scaffolds surrounding other fissures is still associated with basement membrane
|
• impaired migration from the external to internal granule layer
|
• no basement membrane separates neighboring lobules in the cerebellum and remains on the surface
|