Phenotypes for Casp1 Casp4 MGI:5467384 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Casp1^tm1Flv/Casp1^tm1Flv Casp4^del/Casp4^del
Genetic Background	involves: 129S2/SvPas * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp1^tm1Flv mutation (2 available); any Casp1 mutation (41 available)
Casp4^del mutation (5 available); any Casp4 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased incidence of tumors by chemical induction ( J:191239 )

• mice treated with 7,12-Dimethylbenz(a)anthracene/12-O-Tetradecanoylphorbol-13-acetate (DMBA) exhibit later onset and a lower incidence of tumors compared with type mice

integument

integument phenotype ( J:191239 )

N	• untreated or TPA, TNF or EGF-treated keratinocytes exhibit normal proliferation

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:191239 )

• mice treated with 7,12-Dimethylbenz(a)anthracene/12-O-Tetradecanoylphorbol-13-acetate (DMBA) exhibit later onset and a lower incidence of tumors compared with type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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