Phenotypes Associated with This Genotype

Genotype
MGI:5466672

• Allelic Composition: Sp7^tm1Rnis/Sp7^tm1Rnis; Tg(Col2a1-cre)1Bhr/0
• Genetic Background: involves: C57BL * C57BL/6 * CBA/JNCrlj * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Impairment of ossification in various conditional Sp7^tm1Rnis/Sp7^tm1Rnis mice

skeleton

abnormal skeleton development ( J:191589 )

• mice exhibit reduced vascular invasion into cartilage because of insufficient space in non-degraded cartilage tissues indicating disruption in cartilage matric degradation compared to in control mice

• however, mice exhibit normal angiogenesis in the bone collar and apoptosis in hypertrophic chondrocytes

rickets ( J:191589 )

• calcification is inhibited at E17.5 and E18.5

failure of endochondral bone ossification ( J:191589 )

• endochondral ossification stopped at the hypertrophic stage