Phenotypes Associated with This Genotype

Genotype
MGI:5466572

• Allelic Composition: Hormad2^tm1Kura/Hormad2^tm1Kura
• Genetic Background: either: B6.Cg-Hormad2^tm1Kura or (involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:192634 )

♀N • female mice are fertile with normal ovary morphology

azoospermia ( J:192634 )

♂

abnormal female meiosis ( J:192634 )

♀ • incomplete synapsis in pachytene oocytes of fetal females

abnormal male meiosis ( J:192634 )

♂ • more pachytene spermatocytes contain one or a few chromosomes pairs with incomplete synapsis than in wild-type mice

♂ • pachytene spermatocytes rarely exhibit a typical sex body unlike in wild-type mice

♂ • disruption of meiotic sex chromosome inactivation in spermatocytes

♂ • sex body formation in spermatocyte is impaired

abnormal male germ cell apoptosis ( J:192634 )

♂ • confined to the stage IV seminiferous tubule

small testis ( J:192634 )

♂

decreased testis weight ( J:192634 )

♂

male infertility ( J:192634 )

♂

cellular

azoospermia ( J:192634 )

♂

abnormal female meiosis ( J:192634 )

♀ • incomplete synapsis in pachytene oocytes of fetal females

abnormal male meiosis ( J:192634 )

♂ • more pachytene spermatocytes contain one or a few chromosomes pairs with incomplete synapsis than in wild-type mice

♂ • pachytene spermatocytes rarely exhibit a typical sex body unlike in wild-type mice

♂ • disruption of meiotic sex chromosome inactivation in spermatocytes

♂ • sex body formation in spermatocyte is impaired

abnormal male germ cell apoptosis ( J:192634 )

♂ • confined to the stage IV seminiferous tubule

endocrine/exocrine glands

small testis ( J:192634 )

♂

decreased testis weight ( J:192634 )

♂