Phenotypes Associated with This Genotype

Genotype
MGI:5466376

• Allelic Composition: Arf4^{Gt(CSH658)Byg}/Arf4⁺
• Genetic Background: B6.129P2-Arf4^{Gt(CSH658)Byg}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Decreased dendritic spine density in Arf4^{Gt(CSH658)Byg}/Arf4⁺ mice

behavior/neurological

behavior/neurological phenotype ( J:192108 )

N • mice exhibit normal locomotor and exploratory activity (open field test), motor coordination (rotarod) and anxiety-related behaviors (elevated plus maze)

abnormal response to novelty ( J:192108 )

• mice exhibit no difference in the proportion of time exploring an object in a novel or familiar context unlike wild-type mice

• however, mice exhibit normal spatial learning and memory retention

nervous system

decreased dendritic spine density ( J:192108 )

• reduced spine density in the granule cells of the dentate gyrus

decreased miniature excitatory postsynaptic current amplitude ( J:192108 )

• reduced miniature excitatory postsynaptic current amplitude in dentate gyrus granule cells