Phenotypes Associated with This Genotype

Genotype
MGI:5466357

• Allelic Composition: Cebpd^tm1Pfj/Cebpd^tm1Pfj
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased blood uric acid level ( J:116932 )

• decrease in serum levels of urate

decreased circulating lactate level ( J:116932 )

• 90% decrease in serum levels of lactate

abnormal urine homeostasis ( J:116932 )

• 29-fold increase in urinary lactate levels

increased urine uric acid level ( J:116932 )

• 6-fold increase in urinary excretion of urate

renal/urinary system

abnormal urine homeostasis ( J:116932 )

• 29-fold increase in urinary lactate levels

increased urine uric acid level ( J:116932 )

• 6-fold increase in urinary excretion of urate

cellular

increased mammary gland epithelial cell proliferation ( J:103094 )

♀ • the BrdU labeling index is higher in mammary epithelial cells of nulliparous females compared to controls during the proestrus/estrus and metestrus/diestrus phases of the estrus cycle, indicating increased proliferation of these cells

♀ • however, apoptosis levels are similar to controls

endocrine/exocrine glands

increased mammary gland epithelial cell proliferation ( J:103094 )

♀ • the BrdU labeling index is higher in mammary epithelial cells of nulliparous females compared to controls during the proestrus/estrus and metestrus/diestrus phases of the estrus cycle, indicating increased proliferation of these cells

♀ • however, apoptosis levels are similar to controls

abnormal mammary gland epithelium morphology ( J:103094 )

♀ • mean total mammary gland cellular volume occupied by epithelium is higher in adult nulliparous females than in controls

abnormal branching of the mammary ductal tree ( J:103094 )

♀ • with increasing age (by 26 weeks of age), adult nulliparous females exhibit increased ductal arborization showing a higher mean number of mammary ductal branches than wild-type females

♀ • however, mammary gland involution appears normal and no differences in mammary gland morphology, ductal branching or total epithelial content is seen in multiparous females

integument

increased mammary gland epithelial cell proliferation ( J:103094 )

♀ • the BrdU labeling index is higher in mammary epithelial cells of nulliparous females compared to controls during the proestrus/estrus and metestrus/diestrus phases of the estrus cycle, indicating increased proliferation of these cells

♀ • however, apoptosis levels are similar to controls

abnormal mammary gland epithelium morphology ( J:103094 )

♀ • mean total mammary gland cellular volume occupied by epithelium is higher in adult nulliparous females than in controls

abnormal branching of the mammary ductal tree ( J:103094 )

♀ • with increasing age (by 26 weeks of age), adult nulliparous females exhibit increased ductal arborization showing a higher mean number of mammary ductal branches than wild-type females

♀ • however, mammary gland involution appears normal and no differences in mammary gland morphology, ductal branching or total epithelial content is seen in multiparous females