Phenotypes Associated with This Genotype

Genotype
MGI:5466250

• Allelic Composition: Rr249^tm1.1Ebres/Rr249^tm1.1Ebres
• Genetic Background: involves: 129 * BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Hemorrhage in Rr249^tm1.1Ebres/Rr249^tm1.1Ebres embryos

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:191756 )

• mice die between E13.5 and E14.5

hematopoietic system

decreased common myeloid progenitor cell number ( J:191756 )

• from fetal liver hematopoietic precursors

decreased erythroid progenitor cell number ( J:191756 )

• from fetal liver hematopoietic precursors

decreased hematopoietic stem cell number ( J:191756 )

• severe depletion in the fetal liver at E12.5 and E13.5

cardiovascular system

abnormal blood vessel endothelium morphology ( J:191756 )

• discontinuous endothelial cell barrier

hemorrhage ( J:191756 )

• severe at E13.5, including subcutaneous sites in the trunk and the brain

increased vascular permeability ( J:191756 )

• vascular integrity defect

liver/biliary system

small liver ( J:191756 )

liver hypoplasia ( J:191756 )

homeostasis/metabolism

edema ( J:191756 )

• variable at E13.5