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Phenotypes Associated with This Genotype
Genotype
MGI:5465558
Allelic
Composition
Tg(Thy1-APPArc)M8Cagr/Tg(Thy1-APPArc)M8Cagr
Genetic
Background
involves: C57BL/6 * CBA
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No mouse lines available in IMSR.
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phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• both males and females exhibit amyloid beta deposits in the brain, however females show more severe neuropathological alternations than males when compared at the same age and thus all further analysis was performed with females
• females exhibit intracellular amyloid beta aggregates in subiculum and pyramidal cells in CA1 and cortical layer V at 3 months of age, accumulation of diffuse extracellular amyloid beta in subiculum, alveus, and the retropsplenial granular cortex at 4 months of age, diffuse amyloid beta accumulation in thalamus, mammillary bodies, fimbria, fornix, motor cortex, and sensory cortex at 9 months of age, and additional diffuse accumulation in the entorhinal cortex, piriform cortex, lateral septum, and pons/medulla at 12-15 months of age
• females exhibit amyloid beta 40 and amyloid beta 42 immunoreactivity in plaque-like structures in subiculum at 6 months of age, and additionally in the thalamus, alveus, mammillary bodies, lateral septum, and pons/medulla, and around vessel walls in thalamus and subiculum at 12-15 months of age

homeostasis/metabolism
• both males and females exhibit amyloid beta deposits in the brain, however females show more severe neuropathological alternations than males when compared at the same age and thus all further analysis was performed with females
• females exhibit intracellular amyloid beta aggregates in subiculum and pyramidal cells in CA1 and cortical layer V at 3 months of age, accumulation of diffuse extracellular amyloid beta in subiculum, alveus, and the retropsplenial granular cortex at 4 months of age, diffuse amyloid beta accumulation in thalamus, mammillary bodies, fimbria, fornix, motor cortex, and sensory cortex at 9 months of age, and additional diffuse accumulation in the entorhinal cortex, piriform cortex, lateral septum, and pons/medulla at 12-15 months of age
• females exhibit amyloid beta 40 and amyloid beta 42 immunoreactivity in plaque-like structures in subiculum at 6 months of age, and additionally in the thalamus, alveus, mammillary bodies, lateral septum, and pons/medulla, and around vessel walls in thalamus and subiculum at 12-15 months of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:188191


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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory