Phenotypes Associated with This Genotype

Genotype
MGI:5465428

• Allelic Composition: Esr1^tm4.2Ksk/Esr1^tm4.2Ksk
• Genetic Background: involves: C57BL/6 * C57BL/6NTac * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating testosterone level ( J:191182 )

♀ • serum levels elevated 20X in females

increased circulating luteinizing hormone level ( J:191182 )

♀ • serum levels elevated 6.5X in females

endocrine/exocrine glands

abnormal mammary gland development ( J:191182 )

♀ • impaired mammary gland development in adult females

♀ • ductal rudiment is present

reproductive system

abnormal uterus development ( J:191182 )

♀ • uterine proliferation is impaired

growth/size/body

growth/size/body region phenotype ( J:191182 )

♂N • male growth curves are normal between 50 and 200 days of age

increased body weight ( J:191182 )

♀ • females with greater body weights than controls

increased growth rate ( J:191182 )

♀ • steeper growth curve in females relative to controls

♀ • female growth curve is similar to male growth curve

adipose tissue

increased total body fat amount ( J:191182 )

♀ • females have more body fat than controls

skeleton

increased bone mineral density ( J:191182 )

♀ • mean bone mineral density in females is greater than in controls although bone mineral density is highly variable

integument

abnormal mammary gland development ( J:191182 )

♀ • impaired mammary gland development in adult females

♀ • ductal rudiment is present