Phenotypes Associated with This Genotype

Genotype
MGI:5465326

• Allelic Composition: Tlr4^tm1.1Djh/Tlr4^tm1.1Djh
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal enterocyte proliferation ( J:192520 )

• LPS fails to reduce enterocyte proliferation in the colon of newborn mice unlike in wild-type mice

abnormal fibroblast proliferation ( J:192520 )

• mouse embryonic fibroblasts exposed to LPS fail to exhibit a reduction in cell proliferation compared with wild-type cells

immune system

decreased susceptibility to endotoxin shock ( J:192520 )

• mice fail to mount a septic response to the intraperitoneal injection of LPS

• mouse embryonic fibroblasts exposed to LPS fail to exhibit a reduction in cell proliferation compared with wild-type cells

• LPS fails to reduce enterocyte proliferation unlike in wild-type mice

digestive/alimentary system

abnormal enterocyte proliferation ( J:192520 )

• LPS fails to reduce enterocyte proliferation in the colon of newborn mice unlike in wild-type mice