Phenotypes Associated with This Genotype

Genotype
MGI:5465030

• Allelic Composition: Foxn1^nu-2J/Foxn1^nu-2J
• Genetic Background: B6(SJL)-Foxn1^nu-2J/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

athymia ( J:192383 )

immune system

athymia ( J:192383 )

integument

hairless ( J:192383 )

• hair does not grown in and mice remain essentially hairless throughout life

brittle hair ( J:192383 )

• microscopic examination of plucks of the little hair available showed there to be clumps of tangled, broken hairs indicative of fragile hair

abnormal hair follicle bulb morphology ( J:192383 )

• severe follicular dystrophy with clumping, broken hair in histological section at 8 weeks of age

underdeveloped hair follicles ( J:192383 )

abnormal vibrissa morphology ( J:192383 )

• vibrissae of homozygotes may be sparse, short and curled, or absent

absent vibrissae ( J:192383 )

curly vibrissae ( J:192383 )

short vibrissae ( J:192383 )

sparse vibrissae ( J:192383 )

wrinkled skin ( J:192383 )

• wrinkled skin evident by approximately 1 week of age

reproductive system

reduced female fertility ( J:192383 )

decreased litter size ( J:192383 )

• female homozygotes may bear no live pups or have small litter sizes

mortality/aging

premature death ( J:192383 )

• many homozygotes do not survive to wean age, although some do and survive to breed

growth/size/body

decreased body size ( J:192383 )

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:192383 )

• hearing impairment at higher frequencies was found by ABR testing of 2 male homozygotes at 6 weeks of age

endocrine/exocrine glands

athymia ( J:192383 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
T-cell immunodeficiency, congenital alopecia, and nail dystrophy		DOID:0060769	OMIM:601705	J:222308