Phenotypes for H2 Tg(Ins2-Vtcn1)#Xxz Tg(TcraBDC2.5,TcrbBDC2.5)1Doi MGI:5463746 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	H2^g7/H2^g7 Tg(Ins2-Vtcn1)#Xxz/0 Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background	involves: C57BL/6 * NOD * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^g7 mutation (23 available); any H2 mutation (304 available)
Tg(Ins2-Vtcn1)#Xxz mutation (0 available)
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased regulatory T cell number ( J:177612 )

• in the pancreas

decreased interferon-gamma secretion ( J:177612 )

• from CD4+ pancreatic T cells

decreased interleukin-17 secretion ( J:177612 )

• from CD4+ pancreatic T cells

decreased susceptibility to autoimmune diabetes ( J:177612 )

• diabetes disease progression is abrogated compared to in control mice

• however, mice develop insulitis

hematopoietic system

decreased regulatory T cell number ( J:177612 )

• in the pancreas

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 01/06/2026 MGI 6.24