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Phenotypes Associated with This Genotype
Genotype
MGI:5463438
Allelic
Composition
Tg(Thy1-APPArc)M8Cagr/0
Genetic
Background
involves: C57BL/6 * CBA
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phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mutants exhibit normal motor activity, exploratory behavior, and vertical activity in the open-field test at all ages tested
• in the Barnes maze, mutant females exhibit longer latency to find the target hole during the acquisition phase and the reversal learning phase compared to wild-type females, however no differences are seen between mutant and wild-type males, indicating impaired spatial learning and memory in 15 month old females
• in the Barnes maze, mutant females exhibit longer latency to find the target hole during the reversal learning phase compared to wild-type females, indicating impaired long-term learning and memory
• in a delayed alternation test, mutants show a longer latency to find the escape platform at 15 months of age compared to wild-type mice, indicating a minor impairment in working memory

nervous system
• amyloid beta plaques are evident in the subiculum and thalamus at 7 months and 18 months of age, respectively
• amyloid beta deposition is seen around vessel walls and in the parenchyma
• females exhibit higher levels of amyloid beta deposits than males

homeostasis/metabolism
• amyloid beta plaques are evident in the subiculum and thalamus at 7 months and 18 months of age, respectively
• amyloid beta deposition is seen around vessel walls and in the parenchyma
• females exhibit higher levels of amyloid beta deposits than males

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:168288


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory