Mouse Genome Informatics
tg
    Tg(Thy1-APPArc)M8Cagr/0
involves: C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
N
• mutants exhibit normal motor activity, exploratory behavior, and vertical activity in the open-field test at all ages tested (J:168288)
• in the Barnes maze, mutant females exhibit longer latency to find the target hole during the acquisition phase and the reversal learning phase compared to wild-type females, however no differences are seen between mutant and wild-type males, indicating impaired spatial learning and memory in 15 month old females (J:168288)
• in the Barnes maze, mutant females exhibit longer latency to find the target hole during the reversal learning phase compared to wild-type females, indicating impaired long-term learning and memory (J:168288)
• in a delayed alternation test, mutants show a longer latency to find the escape platform at 15 months of age compared to wild-type mice, indicating a minor impairment in working memory

nervous system
• amyloid beta plaques are evident in the subiculum and thalamus at 7 months and 18 months of age, respectively
• amyloid beta deposition is seen around vessel walls and in the parenchyma
• females exhibit higher levels of amyloid beta deposits than males

homeostasis/metabolism
• amyloid beta plaques are evident in the subiculum and thalamus at 7 months and 18 months of age, respectively
• amyloid beta deposition is seen around vessel walls and in the parenchyma
• females exhibit higher levels of amyloid beta deposits than males

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:168288