Phenotypes Associated with This Genotype

Genotype
MGI:5463237

• Allelic Composition: Tg(Prnp-TARDBP*M337V)106Dwc/?
• Genetic Background: involves: C57BL/6 * C3H

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:191785 )

• motor deficits appear by 10 months when tested on a rotarod

decreased grip strength ( J:191785 )

• in hind limbs

nervous system

decreased motor neuron number ( J:191785 )

• modest age dependent decrease in motor neuron number at 10-12 months of age

abnormal spinal cord white matter morphology ( J:191785 )

abnormal spinal cord dorsal column morphology ( J:191785 )

• minor degeneration

abnormal spinal cord lateral column morphology ( J:191785 )

• minor degeneration