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Phenotypes Associated with This Genotype
Genotype
MGI:5462361
Allelic
Composition
Traf3ip2tm1Sbn/Traf3ip2tm1Sbn
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Traf3ip2tm1Sbn mutation (0 available); any Traf3ip2 mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mutants challenged with glomerular basement membrane antibodies in a model of accelerated nephrotoxic nephritis exhibit decreased numbers of neutrophils and monocytes and a trend toward lower counts of macrophages, decreased renal pathology and inflammatory cell infiltrations, indicating protection from development of glomerular basement membrane antibody-induced glomerulonephritis


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/30/2025
MGI 6.24
The Jackson Laboratory