Phenotypes for Fcgr2b Traf3ip2 MGI:5462356 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk Traf3ip2^tm2Sbn/Traf3ip2⁺
Genetic Background	involves: 129S4/SvJae * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2b^tm1Ttk mutation (7 available); any Fcgr2b mutation (44 available)
Traf3ip2^tm2Sbn mutation (0 available); any Traf3ip2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

enlarged spleen ( J:191090 )

increased spleen weight ( J:191090 )

spleen hyperplasia ( J:191090 )

increased germinal center B cell number ( J:191090 )

• increase in the total number of germinal center B cells

increased plasma cell number ( J:191090 )

• increase in the percentage and number of plasma cells

immune system

enlarged spleen ( J:191090 )

increased spleen weight ( J:191090 )

spleen hyperplasia ( J:191090 )

increased germinal center B cell number ( J:191090 )

• increase in the total number of germinal center B cells

increased plasma cell number ( J:191090 )

• increase in the percentage and number of plasma cells

growth/size/body

enlarged spleen ( J:191090 )

increased spleen weight ( J:191090 )

spleen hyperplasia ( J:191090 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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