Phenotypes for Fcgr2b Traf3ip2 MGI:5462346 MGI Mouse

decreased survivor rate ( J:191090 )

• 75% of mutants survive to 12 months of age; this is an 89.7% improvement in survival rate when compared to Fcgr2b nulls heterozygous for Traf3ip2

premature death ( J:191090 )

• 75% of mutants survive to 12 months of age, indicating that 25% die before that time

abnormal T cell morphology ( J:191090 )

• expansion of IFN-gamma producing cells, mainly T cells, in spleens

increased double-negative T cell number ( J:191090 )

• increase in the numbers of double negative T-cells in the lymph nodes

increased IgG level ( J:191090 )

• total serum IgG is increased and IgG deposition in the kidneys

decreased susceptibility to systemic lupus erythematosus ( J:191090 )

• mutants exhibit a reversal of spontaneous germinal center formation, the expansion of plasma cell numbers, and the increased numbers of T effector-memory cells that are seen in Fcgr2b nulls heterozygous for Traf3ip2

• mutants exhibit reduced infiltration of inflammatory cells into kidneys and glomerular pathology is greatly reduced compared to Fcgr2b nulls heterozygous for Traf3ip2

• mutants do not exhibit an increase in CD11b+CD11c- monocytic cells, CD11b+CD11c+ myeloid DCs and CD11c+B220+ plasmacytoid DCs in spleens as seen in Fcgr2b nulls heterozygous for Traf3ip2

increased autoantibody level ( J:191090 )

• presence of anti-nRNP (ribonucleoprotein) antibodies

increased anti-nuclear antigen antibody level ( J:191090 )

increased anti-double stranded DNA antibody level ( J:191090 )

• presence of double-stranded DNA IgG antibodies