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Phenotypes Associated with This Genotype
Genotype
MGI:5462227
Allelic
Composition		 Thbdtm1(THBD)Sltz/Thbdtm1(THBD)Sltz
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thbdtm1(THBD)Sltz mutation (0 available); any Thbd mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality during fetal growth through weaning, incomplete penetrance ( J:191461 )
• fewer than expected mice are present at E17.5 and weaning

homeostasis/metabolism
abnormal enzyme/coenzyme activity ( J:191461 )
• untreated aortic rings and untreated or murine thrombin stimulated lung lysates generate less activated protein C compared with wild-type samples

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory