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Phenotypes Associated with This Genotype
Genotype
MGI:5462061
Allelic
Composition		 Smad4tm2.1Cxd/Smad4tm2.1Cxd
Tg(Dppa3-cre/Esr1*)3Sait/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad4tm2.1Cxd mutation (2 available); any Smad4 mutation (46 available)
Tg(Dppa3-cre/Esr1*)3Sait mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal male meiosis ( J:191052 )
• following tamoxifen treatment at E10.5-E11.5, some male germ cells abnormally enter meiosis at E14.5

cellular
abnormal male meiosis ( J:191052 )
• following tamoxifen treatment at E10.5-E11.5, some male germ cells abnormally enter meiosis at E14.5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory