Phenotypes for Ano1 Avil MGI:5461903 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Ano1^tm1.1Jwo/Ano1^tm1.1Jwo Avil^tm2(cre)Fawa/Avil⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ano1^tm1.1Jwo mutation (0 available); any Ano1 mutation (58 available)
Avil^tm2(cre)Fawa mutation (2 available); any Avil mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:191353 )

N	• mice exhibit normal balance, motor coordination, locomotion and mechanical sensitivities

increased thermal nociceptive threshold ( J:191353 )

• in response to tail immersion in hot water or radiant heat

nervous system

abnormal sensory neuron morphology ( J:191353 )

• dorsal root ganglion sensory neurons exhibit reduced heat-evoked inward chloride current compared with control neurons

integument

integument phenotype ( J:191353 )

N	• mice exhibit normal mechanical sensitivities

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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