Phenotypes Associated with This Genotype

Genotype
MGI:5461824

• Allelic Composition: Frmpd4^tm1.1Pfw/Frmpd4^tm1.1Pfw
• Genetic Background: B6.Cg-Frmpd4^tm1.1Pfw

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal nociception after inflammation ( J:191366 )

♂ • mice treated with Grm5-specific antagonist (2-methyl-6-(phenylethynyl)-pyridine; MPEP) fail to exhibit a reduction in formalin-induced inflammatory pain compared with wild-type mice

♂ • formalin-treated mice exhibit greater response to pain during the second phase, but not the first phase, compared with wild-type mice

decreased thermal nociceptive threshold ( J:191366 )

♂ • 3 days after complete Freund's adjuvant in a model of chronic pain, mice exhibit increased thermal pain compared with wild-type mice

♂ • however, mice exhibit normal basal thermal pain response and initial pain response

nervous system

abnormal neuron morphology ( J:191366 )

♂ • dorsal spinal cord neurons exhibit enhanced Grm5-mediated calcium response compared with wild-type neurons