Phenotypes Associated with This Genotype

Genotype
MGI:5461535

• Allelic Composition: Vdr^tm1.1Sgcg/Vdr^tm1.2Sgcg; Myl2^tm1(cre)Krc/Myl2⁺
• Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:189471 )

N • untreated and isoflurane-treated mice exhibit normal left ventricular systolic and diastolic function

increased myocardial fiber size ( J:189471 )

• in untreated and isoflurane-treated mice

cardiac hypertrophy ( J:189471 )

• in untreated and isoflurane-treated mice

abnormal heart ventricle morphology ( J:189471 )

• untreated and isoflurane-treated mice exhibit a reduction in end-diastolic volume and end-systolic volume compared with control mice

thick interventricular septum ( J:189471 )

• in untreated and isoflurane-treated mice

increased heart left ventricle weight ( J:189471 )

• in untreated and isoflurane-treated mice

thick ventricular wall ( J:189471 )

• untreated and isoflurane-treated mice exhibit increased thickness of the posterior left ventricular free wall compared with control mice

decreased mean systemic arterial blood pressure ( J:189471 )

decreased systemic arterial diastolic blood pressure ( J:189471 )

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:189471 )

N • unlike null homozygotes, mice are not hypocalcemic

increased circulating atrial natriuretic factor ( J:189471 )

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:189471 )

N • unlike null homozygotes, mice do not develop hyperparathyroidism

muscle

increased myocardial fiber size ( J:189471 )

• in untreated and isoflurane-treated mice

growth/size/body

cardiac hypertrophy ( J:189471 )

• in untreated and isoflurane-treated mice