Phenotypes Associated with This Genotype

Genotype
MGI:5461510

• Allelic Composition: Ngf^tm1.1Blhe/Ngf⁺
• Genetic Background: B6.Cg-Ngf^tm1.1Blhe

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Adult Ngf^tm1.1Blhe/Ngf⁺ mice exhibit dilated cardiomyopathy and fibrosis and this phentoype is rescued in Ngfr^tm1Jae/Ngfr^tm1Jae Ngf^tm1.1Blhe/Ngf⁺ mice

mortality/aging

premature death ( J:190893 )

• some mice die by 5 months

• most mice die before 8 months

cardiovascular system

abnormal vascular endothelial cell morphology ( J:190893 )

• many endothelial cells exhibit attenuated cytoplasm with occasional overt rupture and extravasation of erythrocytes unlike in wild-type mice

abnormal myocardium layer morphology ( J:190893 )

• myocardial fibrosis at 8 month without myocyte cell death

abnormal myocardial fiber morphology ( J:190893 )

• focal myofibrillar damage with focal collagen depositions

thin myocardium ( J:190893 )

• at 8 month

abnormal heart left ventricle morphology ( J:190893 )

• decreased left ventricular posterior wall thickness at diastole and systole

dilated heart left ventricle ( J:190893 )

• at 8 month

dilated heart right ventricle ( J:190893 )

• at 8 month

dilated cardiomyopathy ( J:190893 )

decreased cardiac muscle contractility ( J:190893 )

• contractile dysfunction at 2 months

abnormal vascular endothelial cell physiology ( J:190893 )

• mice exhibit microvascular endothelial activation and increased vascular permeability prior to the development of cardiac fibrosis

increased vascular permeability ( J:190893 )

homeostasis/metabolism

edema ( J:190893 )

• perivascular edema in capillary beds

muscle

abnormal myocardium layer morphology ( J:190893 )

• myocardial fibrosis at 8 month without myocyte cell death

abnormal myocardial fiber morphology ( J:190893 )

• focal myofibrillar damage with focal collagen depositions

thin myocardium ( J:190893 )

• at 8 month

dilated cardiomyopathy ( J:190893 )

decreased cardiac muscle contractility ( J:190893 )

• contractile dysfunction at 2 months