Phenotypes Associated with This Genotype

Genotype
MGI:5461350

• Allelic Composition: Gadd45g^tm1Mhol/Gadd45g^tm1Mhol
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal testis development ( J:191095 )

• at E14.5 XY gonads are smaller compared to wild-type controls

• expression analysis indicates early male gonad specification is permanently interrupted in XY gonads

absent testis cords ( J:191095 )

• at E14.5 XY gonads lack testis cords

primary sex reversal ( J:191095 )

• male to female sex reversal with internal reproductive organs in XY mice closely resembling those in XX mice

• ovaries and uteri are comparable in size and shape in XY and XX mice

• only 3.5% of homozygous mice are phenotypically male but the expected percentage of XY mice are found

secondary sex reversal ( J:191095 )

• male to female sex reversal with external genitalia in XY mice closely resembling those in XX mice

infertility ( J:191095 )

• XY females are infertile; however, XX females are fertile

endocrine/exocrine glands

abnormal testis development ( J:191095 )

• at E14.5 XY gonads are smaller compared to wild-type controls

• expression analysis indicates early male gonad specification is permanently interrupted in XY gonads

absent testis cords ( J:191095 )

• at E14.5 XY gonads lack testis cords