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Phenotypes Associated with This Genotype
Genotype
MGI:5460866
Allelic
Composition		 Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Neurog3-cre/ERT2)1Able/0
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Notch1)Dam mutation (1 available); any Gt(ROSA)26Sor mutation (942 available)
Tg(Neurog3-cre/ERT2)1Able mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:190530 )
N
• tamoxifen induction in 8-week old mice did not result in observable differences in pancreatic cell types compared to controls; about 90% of EGFP-labeled (or EYFP-labeled (in Tg(Neurog3-cre/ERT2)1Able/ Gt(ROSA)26Sortm1(EYFP)Cos/+ mice) cells differentiate into insulin-expressing (chromogranin A stained) cells; differentiation is not affected in adult Neurog3-positive cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory